Aspect of Thrombolytic Therapy: A Review

Aspect of Thrombolytic Therapy: A Review

Thrombolytic therapy, also known as clot busting drug, is a breakthrough treatment which has saved untold lives. It has been used in the clinical area to treat venous and arterial thromboembolic complaints which are a foremost cause of death. In 1761, Morgagni lead the way of thrombolytic therapy. Now day's different types of thrombolytic drugs are currently available in market: alteplase, anis...

Review New Approaches to Thrombolytic Therapy

Tissue-type plasmlnogen activator (t-PA), purified from the culture fluid of a stable human melanoma cell line, Is a serlne protease, different from urokinase, with a molecular weight of about 70,000. It is composed of one polypeptlde chain, which Is converted to a two-chain molecule by limited plasmic action. Activation of plasmlnogen to plasmln occurs by cleavage of the Arg 560-Val 561 peptid...

Thrombolytic therapy.

Thrombolytic therapy, which involves the administration of agents designed to increase fibrinolytic capacity, has been utilized in respiratory medicine for more than 50 years. A variety of agents have been used to effect thrombolysis, including urokinase plasminogen activator (uPA) and streptokinase. Tissue plasminogen activator (tPA) has also been used to effect thrombolysis. Both uPA and tPA ...

Thrombolytic Therapy.

The purpose of this communication is to review briefly the agents available at the present time for use in thrombolytic therapy and to indicate why we believe that at the present time streptokinase is the only suitable agent for extended clinical trial. An account will then be given of the use of streptokinase administered by local perfusion in the treatment of peripheral arterial occlusion and...

[Thrombolytic therapy].